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  Treating Acromegaly  

About Acromegaly
Acromegaly is a rare chronic and insidious hormonal disorder that occurs when the pituitary gland produces excess growth hormone (GH). It most commonly affects middle-aged adults and may lead to premature death.

Diabetes mellitus, hypertension, and increased risk of cardiovascular disease are the most serious health consequences of acromegaly. In addition, patients with acromegaly are at an increased risk of developing colon polyps, which can become cancerous.

The prevalence of acromegaly is approximately 60 cases per million population, and the incidence is 3.3 new cases per million per year.1

The word acromegaly comes from the Greek words for "extremities" (acro) and "great" (megaly), because one of the most common symptoms of this condition is abnormal growth of the hands and feet.

Acromegaly Symptoms and Sandostatin Treatment

 
Causes

Acromegaly is caused by prolonged overproduction of growth hormone (GH), which results in excessive production of insulin-like growth factor I (IGF-I). In 98 percent of cases, GH overproduction is caused by a pituitary adenoma.
 
Symptoms

Early signs and symptoms of acromegaly may be mistaken for aging or symptoms of other diseases, which can make the early diagnosis of this disease challenging. Early detection is a goal in the management of acromegaly because the pathologic effects of increased growth hormone (GH) production are progressive.
 
Diagnosing

If it is suspected that a patient has acromegaly, a 2-step screening is recommended. Measurements of growth hormone (GH) and/or insulin-like growth factor-I (IGF-I) levels can be taken to help confirm the diagnosis.
 
Treatment

Frequently, adequate control of acromegaly calls for a combination of two or more of the current treatment options.
 
Case Studies

Case studies illustrate the challenges of diagnosing acromegaly.
 
 
Learn More
Conferences
FAQ
Resources for patients
Acromegalyonline.com
Symptom Checklist for Acromegaly

1NIDDK. Acromegaly. [www.niddk.nih.gov/health/endo/pubs/acro/acro.htm] from 'About Acromegaly,' http://www.sandostatin.com/acromegaly/index.jsp