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Early detection and diagnosis of acromegaly followed by appropriate treatment can help prevent the development of serious or more permanent complications.

  • Step 1: Initial Suspicion Based on Clinical Features1
    • Changes in physical appearance
    • Decline in overall health
  • Step 2: Confirmation of Disease Through Biochemical Testing2
    • IGF-1
    • GH measurement through OGTT
    • Random GH testing
  • Step 3: Locating the Pituitary Tumor1,3
    • MRI or CT

Recommended algorithm for the diagnosis of acromegaly3

Sandostatin® LAR® Diagnosis of Acromegaly

The difficulty of early diagnosis results from several challenges4,5:

  • Since symptoms develop gradually, time is required for them to be recognized by patients and physicians
  • Patients may exhibit a variety of different clinical signs and symptoms, since they may have any combination of the common symptoms

CT, computerized tomography; GH, growth hormone; GHRH, growth hormone–releasing hormone; IGF-1, insulin-like growth factor-1; MRI, magnetic resonance imaging; OGTT, oral glucose tolerance test.

Read more about effective management of acromegaly.

1. National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, US Department of Health and Human Services. Acromegaly. Bethesda, MD: National Institutes of Health; 2008. NIH publication 08-3924. 2. Lugo G, Pena L, Cordido F. Clinical manifestations and diagnosis of acromegaly. Int J Endocrinol. 2012:540398. doi: 10.1155/2012/540398. 3. Melmed S. Medical progress: acromegaly. N Engl J Med. 2006;355(24):2558-2573. 4. Molitch ME. Clinical manifestations of acromegaly. Endocrinol Metab Clin North Am. 1992;21(3):597-614. 5. Chanson P, Salenave S. Acromegaly. Orphanet J Rare Dis. 2008;3:1-17.

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